Option Explicit
Private Declare Function GetPixel Lib "gdi32" _
     (ByVal hdc As Long, ByVal x As Long, ByVal Y As Long) As Long
Private Declare Function SetPixelV Lib "gdi32" _
     (ByVal hdc As Long, ByVal x As Long, _
      ByVal Y As Long, ByVal crColor As Long) As Long
Private tmpPic As Picture

Private Sub Form_Load()
Picture1.ScaleMode = 3	 '设为Pixel
Picture1.AutoRedraw = True  '设定所有Pixel的改变不立即在pictureBox上显示
Set tmpPic = Picture1.Picture
End Sub

Private Sub Command1_click()
Dim width5  As Long, heigh5 As Long, rgb5 As Long
Dim hdc5 As Long, i As Long, j As Long
Dim bBlue As Long, bRed As Long, bGreen As Long
Dim Y As Long
width5 = Picture1.ScaleWidth
heigh5 = Picture1.ScaleHeight
hdc5 = Picture1.hdc
For i = 1 To width5
   For j = 1 To heigh5
       rgb5 = GetPixel(hdc5, i, j)
       bBlue = Blue(rgb5)
       bRed = Red(rgb5)
       bGreen = Green(rgb5)
       Y = (9798 * bRed + 19235 * bGreen + 3735 * bBlue) \ 32768
       rgb5 = RGB(Y, Y, Y)
       SetPixelV hdc5, i, j, rgb5
   Next j
 Next i
Set Picture1.Picture = Picture1.Image  '此时才真正显示Picture
End Sub

Private Function Red(ByVal mlColor As Long) As Long
	Red = mlColor And &HFF
End Function
Private Function Green(ByVal mlColor As Long) As Long
	Green = (mlColor \ &H100) And &HFF
End Function
Private Function Blue(ByVal mlColor As Long) As Long
	Blue = (mlColor \ &H10000) And &HFF
End Function